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It suppresses IL-6 and TNF- production while enhancing IL-10 production in macrophages, and inhibits the mTOR/STAT3 pathway in T cells, thereby reducing proinflammatory Th17 cells and cytokines such as IL-17 and IL-22, while promoting regulatory T-cell (Treg) differentiation (21)

Moreover, insulin promotes adipocytes proliferation by stimulating the expression of several factors such as neuropeptide Y (Yang et al., 2008)

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Dose-Response Patterns Documented by Sources Topical research uses cosmetic concentrations (0.1-3% formulations)

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Patients taking the 15 mg dose lost an average of roughly 21% of their body weight over 72 weeks